Archetype Arcadia is a dark, sci-fi visual novel set in a post-apocalyptic world where a mysterious disease called the 'Original Sindrome' has wiped out most of humanity. The story revolves around Rust and his sister, roaming empty lands and searching desperately for other humans alive. All other humans have supposedly fallen victim to the disease which causes those inflicted to suffer from insanity, sensory illusions, and uncontrollable self-destructive urges. The only way to control those symptoms is by spending time inside a virtual game called Archetype Arcadia.