This volume celebrates the history of the Philosophy and Medicine series with a retrospective assessment of the impact of the series over 50 years, written by some who were involved from the beginning, and others who have been influenced by the series. The Philosophy of Medicine book series was founded in 1975, inspired by remarkable new technologies that challenged our understanding of medicine’s abilities and purpose. These technologies raised challenges that required deeper conceptual analysis and the tools of philosophy to address. Since its inception, the series has published 150 volumes addressing topics from assisted reproduction to end-of-life care; the history of medical ethics; international approaches to philosophy and medicine; clinical ethics and clinical judgment; brain death; and more. A must-read for anyone specializing in or interested in philosophy of medicine.