Autism disorders are a very complicated and multifarious group of chronic disorders that are characterized by early impairment in social interaction and communication. The diagnosis of autism is clinical and is based on the presence of characteristic diagnostic manifestations resulting from impaired social interaction and communication, which cause the two major diagnostic features of autism: the lack of appropriate responsiveness to one's own name and the lack of eye contact. This book describes a dysmorphic boy with autism whose phenotypic presentation does not align with any currently known genetic syndromes associated with autism, suggesting the possibility of a novel syndromic autism phenotype. This book highlights a unique clinical entity "Syndromic Autism with Distinct Craniofacial Dysmorphism".