The field of orthodontics is continually evolving, with new techniques and materials being developed to enhance treatment outcomes and patient satisfaction. One such innovation is the use of autologous leukocyte-platelet-rich fibrin (L-PRF), a biomaterial derived from the patient's own blood, which has shown promise in accelerating healing and tissue regeneration. This book aims to evaluate the efficacy of L-PRF in comparison to a control on the rate of maxillary canine retraction when placed in the first premolar extraction socket.Through a comprehensive review of clinical studies, we delve into the potential benefits and limitations of L-PRF in orthodontic treatment. Our goal is to provide a thorough understanding of how this biomaterial can be integrated into clinical practice to improve treatment efficiency and patient outcomes. We hope that this book will serve as a valuable resource for orthodontists, researchers, and students who are keen to explore cutting-edge advancements in orthodontic care.