This book presents the refereed proceedings of the 6th International Conference on Advanced Machine Learning Technologies and Applications (AMLTA 2021) held in Cairo, Egypt, during March 22–24, 2021, and organized by the Scientific Research Group of Egypt (SRGE). The papers cover current research Artificial Intelligence Against COVID-19, Internet of Things Healthcare Systems, Deep Learning Technology, Sentiment analysis, Cyber-Physical System, Health Informatics, Data Mining, Power and Control Systems, Business Intelligence, Social media, Control Design, and Smart Systems.