This book offers a broad overview of the field of cognitive engineering and neuroergonomics, covering emerging practices and future trends toward the harmonious integration of human operators and computational systems. It gathers both theoretical and practice-oriented studies on mental workload and stress, activity theory, human reliability, error and risk. It covers applications in various field, and corresponding strategies to make assistive technologies more user-oriented. Further, the book describes key advances in our understanding of cognitive processes, including mechanisms of perception, memory, reasoning, and motor response, with a particular focus on their role in interactions between humans and other elements of computer-based systems. Gathering the proceedings of the AHFE 2021 Conferences on Neuroergonomics and Cognitive Engineering, Industrial Cognitive Ergonomics and Engineering Psychology, and Cognitive Computing and Internet of Things, held virtually on July 25-29, 2021, from USA, this book offers extensive information and a thought-provoking guide for researchers and practitioners in cognitive engineering, neuroergonomics and their applications.