Atelier Resleriana: The Red Alchemist & the White Guardian takes players on a mysterious and cozy adventure alongside new protagonists Rias Eidreise, an adventurer with a talent for alchemy, and Slade Clauslyter, a young man capable of opening entrances to dimensional paths leading to alternate dimensions. These two heroes will join forces in an attempt to discover the reason for the disappearance of the inhabitants of Hallfein, while also trying to follow in the footsteps of their loved ones and restore their hometown. During their journey, they will meet various characters who will help them, including familiar faces from the Atelier series such as Sophie Nuenmuller, Razeluxe Meitzen, Totori Helmold, and Wilbell Voll-Ersleid.