U.S. Marshal James Creed has known loss, starting from the untimely death of his wife and daughter in a sudden fire. His work, chasing down and arresting outlaws across the Wild West, is all he has left to live for. Then one day, in 1876, the infamous killer Corwin Blake catches Creed by surprise and guns him down. Creed awakes after a mysterious young woman resurrects him in a basement laboratory beneath a brothel. Half alive, Creed feels torn between his need for justice and his desire to fall back into the peace of death. Creed's instincts drive him to protect the city of Santa Cruz, California, from the outlaws it harbors while searching for Blake. He uncovers a secret criminal organization, likely protecting Blake, determined to use resurrection technology for its own ends. The former marshal, now faster, stronger, and a more deadly shot than ever before, must work with a brothel madam, a bounty hunter, and the remaining marshals to uncover the criminal syndicate before they can misuse the machines of rebirth and create more mindless zombies. Meanwhile, he must also stop Blake, before the outlaw kills the only people he cares about. His own death can wait.