As the demand for advanced technologies to revolutionize patient care intensifies, the medical industry faces a pressing need to confront challenges hindering the assimilation of AI-enhanced healthcare systems. Issues such as data interoperability, ethical considerations, and the translation of AI advancements into practical clinical applications pose formidable hurdles that demand immediate attention. It is within this context of challenges and opportunities that the book, Clinical Practice and Unmet Challenges in AI-Enhanced Healthcare Systems promises to pave the way for a transformative era in healthcare. The book serves as a comprehensive guide for academic scholars, researchers, and healthcare professionals navigating the dynamic landscape of data-driven, AI-enhanced healthcare. By showcasing the latest advancements, the book empowers its readers to not only comprehend the existing frontiers in data sciences and healthcare technologies but also to actively contribute to overcoming obstacles. Through detailed case studies and practical guidance, the publication equips its audience with the skills necessary to implement AI in various clinical settings.