Moustafa Nawito describes in detail the development process of a novel platform of Readout Integrated Circuits (ROICs), which enable the realization of miniaturized multi-parameter biomedical implants intended for long-term in-vivo monitoring. He presents new circuits and techniques for fully integrated sinusoidal generation, electrochemical impedance spectroscopy as well as on-chip measurement of pH levels, oxygen concentration and temperature. The author draws conclusions of the development process and delivers guidelines for further innovations.