The two volume set LNCS 11678 and 11679 constitutes the refereed proceedings of the 18th International Conference on Computer Analysis of Images and Patterns, CAIP 2019, held in Salerno, Italy, in September 2019. The 106 papers presented were carefully reviewed and selected from 176 submissions The papers are organized in the following topical sections: Intelligent Systems; Real-time and GPU Processing; Image Segmentation; Image and Texture Analysis; Machine Learning for Image and Pattern Analysis; Data Sets and Benchmarks; Structural and Computational Pattern Recognition; Posters.