Congenital toxoplasmosis (CT), caused by transplacental transmission of Toxoplasma gondii during maternal primary infection (PI), presents in variable clinical forms in newborns (NN), ranging from severe neurological damage to sub-clinical forms. The aim of this study was to analyze the epidemiological, clinical, diagnostic and therapeutic aspects of CT . An observational and descriptive study was carried out over four years, including 78 (NN) suspected TC. Antenatal diagnosis was based on a qualitative PCR test for parasite DNA in amniotic fluid. Neonatal serology included IgG and IgM testing by electrochemiluminescence, IgM testing by ISAGA and comparative IgG/IgM profiles (mother-NN) by Western blot. TC was excluded in 31 NN and confirmed in 10 others (13%). 8 NN were clinically asymptomatic and 2 developed retinochoroiditis. All were treated with pyrimethamine-sulfadiazine and folinic acid. The management of CT is complex. A national prevention program should be set up.