This book introduces students to the complex landscape of state-local intergovernmental relations today. Each chapter illustrates conflict and cooperation for policy problems including the response to the COVID-19 pandemic, environmental regulation, marijuana regulation, and government management capacity. The contributors, leading experts in the field, help students enhance their understanding of the importance of state-local relations in the U.S. federal system, argue for better analysis of the consequences of state-local relations for the quality of policy outcomes, and introduce them to public service career opportunities in state and local government.