This book constitutes the refereed proceedings of the 24th International Symposium on Distributed Computing, DISC 2010, held in Cambridge, CT, USA, in September 2010. The 32 revised full papers, selected from 135 submissions, are presented together with 14 brief announcements of ongoing works; all of them were carefully reviewed and selected for inclusion in the book. The papers address all aspects of distributed computing, and were organized in topical sections on, transactions, shared memory services and concurrency, wireless networks, best student paper, consensus and leader election, mobile agents, computing in wireless and mobile networks, modeling issues and adversity, and self-stabilizing and graph algorithms.