Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Prools, leading experts provide an indepth view of key prools that are commonly used in drug discovery laboratories. Covering both classic and cuttingedge techniques, this volume explores computational docking, quantitative structureactivity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNAmicroarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, stepbystep, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Prools serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.
Research in the pharmaceutical sciences and medicinal chemistry has taken an important new direction in the past two decades with a focus on large molecules, especially peptides and proteins, as well as DNA therapeutics. In Drug Design and Discovery: Methods and Prools, leading experts provide an indepth view of key prools that are commonly used in drug discovery laboratories. Covering both classic and cuttingedge techniques, this volume explores computational docking, quantitative structureactivity relationship (QSAR), peptide synthesis, labeling of peptides and proteins with fluorescent labels, DNAmicroarray, zebrafish model for drug screening, and other analytical screening and biological assays that are routinely used during the drug discovery process. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials, stepbystep, readily reproducible laboratory prools, and tips on troubleshooting and avoiding known pitfalls. Thorough and accessible, Drug Design and Discovery: Methods and Prools serve as a vital laboratory reference for pharmaceutical chemists, medicinal chemists, and pharmacologists as well as for molecular biologists.
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