E-learning allows students to pace their studies as per their own obligations, making learning achievable to people who don't get enough spare time for learning, hence, they can schedule their lessons accordingly; as well as to people who live far away from educational institutions or are unable to attend classes because of physical or medical reasons. Therefore, cultural, geographical and physical hurdles can be overcome by E-learning that makes it possible for students to choose their own path and time for learning different courses. This book deals with the challenges that are faced in E-learning, unveiling new ways to understand and confer questions linked with long-distance and lifelong learning, E-learning for people with special demands and, finally, discussing a case study about the relationship between the quality of cooperation and the quality of knowledge achieved in experiences of E-learning formation.