El sabueso de los Baskerville, es la tercera novela de Arthur Conan Doyle que tiene como protagonista principal a Sherlock Holmes. La novela está principalmente ambientada en Dartmoor, en Devon en el Condado Oeste de Inglaterra. Conan Doyle escribió esta historia poco después de regresar de Sudáfrica, donde había trabajado como voluntario médico en The Langman Field Hospital en Bloemfontein. Fue asistido en el argumento por un periodista de 30 años de edad del Daily Express llamado Bertram Fletcher Robinson. Sus ideas provienen de la leyenda de Richard Cabell, que fue la inspiración de la leyenda de los Baskerville. Su tumba se puede ver en un pueblo llamado Buckfastleigh.
Sir Charles Baskerville, baronet, is found dead on the grounds of his country house, Baskerville Hall. The cause is ascribed to a heart attack. Fearing for the safety of Sir Charles's nephew and the only known heir, Sir Henry Baskerville, Dr James Mortimer travels to London and asks Sherlock Holmes for help in figuring out the case.
Mortimer explains that the Baskerville family is afflicted by a curse. According to an old account, said to have been written in 1742 and describing events which had occurred a century earlier still, during the English Civil War, Hugo Baskerville was infatuated with a farmer's daughter. He kidnapped her and imprisoned her in his bedroom. She escaped and the furious Baskerville offered his soul to the devil if he could recapture her. Aided by friends, he pursued the girl onto the desolate moor. Baskerville and his victim were found dead. She had died from fright, but a giant spectral hound stood guard over Baskerville's body. The hound tore out Baskerville's throat, then vanished into the night.