In a fast changing world governed by innovative Enterprise Services and the Future Internet, the issue of Enterprise Interoperability is no longer limited to the interoperation of systems within a single company, but has become a much greater multi-view issue of interoperability throughout a Network of Enterprises. This book contains the proceedings of 13 workshops presented as short papers and discussions held at each workshop. The workshops were co-located with the I-ESA’12 Conference organized by the Polytechnic University of Valencia, Spain. Complementary to the conference program, the workshops aimed at exploiting new issues, challenges and solutions for Enterprise Interoperability. The scope of the workshops spanned a wide range of interoperability issues in Service Science and Innovation, Model Driven Interoperability, Service Oriented Architectures, Factories of the Future, Enterprise Networks and Management, SME Aspects and Standards.