This book hopes to stimulate discussion about how entrepreneurship and innovation contribute to growing inequalities in territories. This will help bridge the gap between research and practice on the role of territory dynamics and regional development.The book begins by examining the growing inequality in regions, which has resulted in lagging economic development. The need to shift current economic policy towards spatial inequality through harnessing the innovative capabilities of regions is examined. The book puts forth a case for reversing the inequality that is evident in lagging regions as a way to reinvigorate territories.The book should appeal to researchers, policy makers, business leaders and the general public interested in territorial dynamics and development.