Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a book series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of central nervous system (CNS) and other nerve disorders. The scope of the book series covers a range of topics including the medicinal chemistry, pharmacology, molecular biology and biochemistry of contemporary molecular targets involved in neurological and CNS disorders. Reviews presented in the series are mainly focused on clinical and therapeutic aspects of novel drugs intended for these targets. Frontiers in Clinical Drug Research - CNS and Neurological Disorders is a valuable resource for pharmaceutical scientists and postgraduate students seeking updated and critical information for developing clinical trials and devising research plans in the field of neurology. The sixth volume of this series features reviews that cover the following topics: -Depression, Insomnia and Atypical Antidepressants-Combination Therapy of Hypothermia for Hypoxic Encephalopathy in Neonates-Development of a "Theranostic Nano-Bullet" for Tinnitus-Dexmedetomidine: From Basic Science to Clinical Application of Brain Protection-Protein Misfolding, Aggregation, Amyloid Formation in Neurodegenerative Diseases