This book represents the combined peer-reviewed proceedings of the Sixth International Symposium on Intelligent Distributed Computing — IDC~2012, of the International Workshop on Agents for Cloud — A4C~2012 and of the Fourth International Workshop on Multi-Agent Systems Technology and Semantics — MASTS~2012. All the events were held in Calabria, Italy during September 24-26, 2012. The 37 contributions published in this book address many topics related to theory and applications of intelligent distributed computing and multi-agent systems, including: adaptive and autonomous distributed systems, agent programming, ambient assisted living systems, business process modeling and verification, cloud computing, coalition formation, decision support systems, distributed optimization and constraint satisfaction, gesture recognition, intelligent energy management in WSNs, intelligent logistics, machine learning, mobile agents, parallel and distributed computational intelligence, parallel evolutionary computing, trust metrics and security, scheduling in distributed heterogenous computing environments, semantic Web service composition, social simulation, and software agents for WSNs.