Exciting papers by leading researchers are integrated in this volume with presentations having direct clinical relevance: thus, the latest scientific advances in aging research are coupled with reports on how these advances are being applied to longevity medicine. Topics include oxidative stress, genetic/biochemical mechanisms, hormone therapy, nutrition, fitness, and exercise, all as they pertain to aging. In exploring the links between the latest basic gerontological research and the practice of longevity medicine, the current challenges faced by both scientists and clinicians engaged in combating aging and its consequences are presented here. This volume is readily accessible to the educated reader who is interested in learning more about how to reduce the negative impact of aging on human health and longevity. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.