This book presents papers from the 5th International Conference on Smart Learning Ecosystems and Regional Development, which promotes discussions on R&D work, policies, case studies, entrepreneur experiences, with a particular focus on understanding the relevance of smart learning ecosystems for regional development and social innovation, and how the effectiveness of the relation of citizens and smart ecosystems can be boosted. The book explores how technology-mediated instruments can foster citizens’ engagement with learning ecosystems and territories, providing insights into innovative human-centric design and development models/techniques, education/training practices, informal social learning, innovative citizen-driven policies, and technology-mediated experiences and their impact. As such, it will inspire the social innovation sectors and ICT, as well as economic development and deployment strategies and new policies for smarter proactive citizens.