Malaria is an infectious disease that is spread by mosquitoes and affects humans and other animals. Common symptoms of malaria are tiredness, headaches, vomiting and fever. Severe symptoms can invlove seizures, yellow skin, coma or death. Normally, the symptoms start to occur ten to fifteen days after the infected mosquito bites. If the malaria infection is not treated properly, it can reoccur but the reinfection causes milder symptoms. Malaria is caused by the micro-organisms of Plasmodium group and is most commonly spread by an infected female Anopheles mosquito. When an infected female Anopheles mosquito bites, it introduces the parasites into the person’s blood from its saliva. There are five species of Plasmodium that can infect and spread by humans. This book is a compilation of chapters that discuss the clinical approaches of malaria. It brings forth some of the unexplored aspects of this disease. This book includes contributions of experts and scientists which will provide innovative insights into this field.