The management of complex cases in complete denture prosthodontics requires a multidisciplinary and individualized approach. These cases often involve anatomical, functional, or psychological challenges that go beyond standard protocols. Common complexities include severe alveolar ridge resorption, maxillomandibular discrepancies, soft tissue abnormalities, and patients with a history of unsuccessful prosthetic experiences.A thorough clinical evaluation is essential, incorporating detailed medical and dental histories, radiographic assessments, and functional analysis. Special attention must be given to the patient's expectations, adaptive capacity and psychological disposition, as these factors significantly influence treatment outcomes.Technical precision is critical in such cases. The use of advanced impression techniques, customized occlusal schemes, and precise jaw relation records can significantly improve denture stability and comfort. In some instances, adjunctive surgical procedures or implant-supported prostheses may be necessary to achieve optimal results.Ultimately, successful management depends on clear communication, patient education, and a strong clinician-patient.