The 12-volume set LNCS 15001 - 15012 constitutes the proceedings of the 27th International Conferenc on Medical Image Computing and Computer Assisted Intervention, MICCAI 2024, which took place in Marrakesh, Morocco, during October 6–10, 2024.MICCAI accepted 857 full papers from 2781 submissions. They focus on neuroimaging; image registration; computational pathology; computer aided diagnosis, treatment response, and outcome prediction; image guided intervention; visualization; surgical planning, and surgical data science; image reconstruction; image segmentation; machine learning; etc.