Supported by an extensive review of migraine pathogenesis and more than 200 case histories gleaned from the authors' personal experiences, this guide proposes two radical new concepts: all primary headaches are fundamentally a form of migraine and everyone may experience some manifestation of the migraine process in their life. Offering an in-depth overview of the migraine mechanism, including discussions of the neurogenic, vascular, platelet, and serotonin related components of the process, this source supplies extensive illustrations of the neuroanatomical structures involved in migraine and the latest insights from functional neuroimaging using BOLD fMRI and PET.