This book highlights the importance of phyhemicals and mihondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phyhemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mihondria, organelles within a cell, are a critical target for phyhemicals in regulating the initiation, promotion, and progression of cancer.
The book is divided into three parts to better communicate the important findings related to phyhemicals and mihondria in cancer research. The first part describes updates on environmental and genetic factors causing cancer initiation and progression, the role of mihondria function in regulating the process of tumorigenesis, and the role of mihondria in regulating cell death such as apoptosis, autophagy, and necroptosis. The second part focuses on the elucidation of key target proteins that could be exploited for cancer prevention, an the role of phyhemicals in cancer prevention, updates on basic research related to phyhemicals action critical for cancer prevention, and updates on translational knowledge on cancer prevention by phyhemicals. The third part provides updates on phyhemicals targeting mihondria for cancer therapy, an overview of action of phyhemicals on cancer stem cells, updates on the role of microRNA in phyhemicals-based therapy of cancer, and updates on phyhemicals-based translation research on therapy for metastatic cancer.