This book addresses the therapeutic strategies to target mihondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mihondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mihondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mihondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mihondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mihondrial biology, the role of mihondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mihondria in context with drug development and clinical applications.
This book addresses the therapeutic strategies to target mihondrial metabolism in diseases where the function of that organelle is compromised, and it discusses the effective strategies used to create mihondrial-targeted agents that can become commercially available drug delivery platforms. The consistent growth of research focused in understanding the multifaceted role of mihondria in cellular metabolism, controlling pathways related with cell death, and ionic/redox regulation has extended the research of mihondrial chemical-biological interactions to include various pharmacological and toxicological applications. Not only does the book extensively cover basic mihondrial physiology, but it also links the molecular interactions within these pathways to a variety of diseases. It is one of the first books to combine state-of-the-art reviews regarding basic mihondrial biology, the role of mihondrial alterations in different diseases, and the importance of that organelle as a target for pharmacological and non-pharmacological interventions to improve human health. The different chapters highlight the chemical-biological linkages of the mihondria in context with drug development and clinical applications.
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