This book exhibits the study of spline collocation methods with different approaches to solve the linear, nonlinear, and coupled nonlinear boundary value problems. The various features of the spline collocation technique expand the field of the numerical solution to the differential equations. A special emphasis is given to the applicability and reliability of the method of spline collocation when the special functions interpolate the solutions to various types of differential equations occurring in the study of several physical phenomena in engineering sciences.it is worth mentioning that the spline collocation technique with all the above approaches is helpful in solving various types of problems such as Sandwich Beam Problem, Magneto hydro Dynamics Problems, Fluid flow problems, etc. The effects of changes in particular parameters on the solution to the problems are shown numerically as well as graphically.