Provides a tutorial on the computational tools that use mathematical optimization concepts and representations for the curation, analysis and redesign of metabolic networks
Organizes, for the first time, the fundamentals of mathematical optimization in the context of metabolic network analysis
Reviews the fundamentals of different classes of optimization problems including LP, MILP, MLP and MINLP
Explains the most efficient ways of formulating a biological problem using mathematical optimization
Reviews a variety of relevant problems in metabolic network curation, analysis and redesign with an emphasis on details of optimization formulations
Provides a detailed treatment of bilevel optimization techniques for computational strain design and other relevant problems