Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect modern pharmaceutical compacting techniques, this second edition of
Pharmaceutical Powder Compaction Technology
guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.
This unique reference covers:
The physical structure of pharmaceutical compacts
Bonding phenomena that occur during powder compaction
Compression mechanisms of pharmaceutical particles
Theories and basic principles of powder compaction
New topics include:
Compaction data analysis techniques
The migration of powder constituents into commercial manufacture
Instrumentation for compaction
Compaction functionality testing, which is likely to become a USP requirement
Design space for compaction
Metrics required for scalability in tablet compression
Interactive compaction and preformulation database for commonly used excipients