Coronary Heart Disease (CHD) and Diabetes Mellitus (DM) are epidemics globally and are closely related to lifestyle-based disorders. Prevention and treatment are essential steps to control the mortality rate. Management of CHD with DM is critical and challenging with invasive surgical procedures. Enhanced External Counter Pulsation (EECP) is a non-invasive treatment procedure approved by the United States Food and Drug Administration (FDA) for coronary heart disease patients. EECP is an effective non-invasive treatment for diabetic CHD patients. This non-invasive therapy may equally improve the physical, biochemical, and clinical parameters with the physical functional capacity of diabetic and CHD patients. EECP may also improve the HRQoL of diabetic and non-diabetic CHD patients. EECP treatment may improve glycemic control, clinical symptoms of CHD patients with diabetes mellitus. This treatment may be useful for glycemic control and coronary heart disease management of diabetic CHD patients. Prevention and Disease Management can be possible with such a Non-Invasive Integrative Approach to deal with Diabetes and Coronary Heart Disease.