This book is an invitation to explore and further understand the many facets that make game-based approaches a truly interesting and effective tool to teach and train in the 21st century. It includes thirteen chapters with content initially presented at the 6th Irish Conference on Game-Based Learning, a conference held at Trinity College Dublin this year, where researchers, practitioners, students and other stakeholders meet and share their interest in games and education. These chapters touch on some very important topics including social change, gamification, language learning, and medical training. Together, these chapters illustrate the advancements in the field of Game-Based Learning, the challenges faced by developers and educators, as well as the opportunities that this medium can offer.