Proteomics was developed for the rapid identification of all of the proteins expressed by a cell or tissue a goal that has yet to be achieved for any species. Current goals of proteomic research are more varied and directed toward the systematic determination of diverse properties of proteins.Application of proteomics into the field of dentistry depends on how best oral health care practitioners will incorporate this into their practice as it requires a thorough knowledge of human genetics and application of new diagnostic and therapeutic technologies. The proteomic tools can help to fill the gaps of the unexplored aspects of periodontal health and periodontal disease.