The book begins with rich descriptions of the experience of despair, drawn from real life case studies from the author’s clinical practice, and a review of current evidence of suicide prevalence, risk and protective factors. A review of theories about suicide highlights two contemporary explanatory models: Integrated Motivational—Volitional (IMV) model, with focus on perceptions of defeat and entrapment; and Interpersonal Theory (IPT), with focus on thwarted belongingness and perceived burdensomeness. The book provides an overview of recent analyses of how literary and poetic texts confront the dilemma of existence in the face of grief and loss, and how literary readings can act as points of transformation.