Shock is caused by the decreased flow of blood to the body tissues due to circulatory system related problems. Sepsis refers to a life-threatening condition where the body causes injury to its own organs and tissues in response to an infection. When sepsis lowers the blood pressure to the extent where it does not improve after fluid replacement, it is known as septic shock. Sepsis happens due to an inflammatory immune response which is triggered by an infection. Septic shock is usually caused by bacteria but it can also be caused by fungi, parasites or viruses. It generally affects the lungs, urinary tract, brain or skin. Fever, increased breathing and heart rate, and confusion are some of its common signs and symptoms. Severe sepsis results in organ dysfunction and poor blood flow. This book provides significant information to help develop a good understanding of sepsis and septic shock. Different approaches, evaluations, methodologies and advanced studies have been included herein. Those in search of information to further their knowledge will be greatly assisted by this book.