Smugglers 2: The Sheriff picks up where Smugglers 1 left off. A small-town sheriff finds the money Isabelle had taken off with and decides to keep the loot for himself. He retires and disappears, knowing that he must lay low and not use the cash until he can unravel the mystery behind his find. He relocates to Tucson, Arizona and creates a new life where he falls in love. Unable to use Isabelle's money, he makes contact with a Mexican Cartel and gets into the smuggling business. He is living the good life when things with the Cartel go bad; they kidnap and kill his woman. Seeking revenge, the sheriff uses his past as a Marine sniper to rob and kill the Cartel's men as he stays in the business to remain close to his victims. He soon takes a partner who like himself is suffering from a mid-life crisis. They both love the adrenaline rush from a gun fight, so the sheriff trains his new partner to be his spotter. They hook up with two beautiful dancers who travel with them for the drugs, sex and money. Their killing spree takes them from Tucson to Key West, ending up at the marina where it all started.