The Abraxas Stone is a sequel to the paranormal thriller The Nexus, in which Sykes, its gay protagonist, discovered the origin of his extrasensory powers: a covert, prenatally conducted genetics experiment. Semi-conscious, Sykes finds himself in a familiar room and begins to recall the cross-country road trip that got him there. Accompanied respectively by an eccentric transient, a pixie hacker's cyber-ghost, a mystical Mexican Indian, and a duplicitous evangelical healer with whom Sykes becomes emotionally involved, he attempts to evade black ops agents for as long as possible. While trying to maintain his sanity, control his extraordinary psychic abilities, and protect a mystical gemstone, he slowly falls victim to both an adversary who wants to use the talisman selfishly and a government agency that plans to use Sykes as a secret weapon. What they don't realize is that unseen forces are at work on the hero's behalf.