What do you get when you combine evil microbes trying to harm the skin and a super detective skilled at Body System Disease Investigations? You get crime-solving super sleuth Annie Biotica. Readers join Annie's team: read the case, check out a line-up of the disease suspects, test the body system for infection, and help Annie Biotica and her science team crack the case. These engaging and easy-to-read books use the scientific method to decipher symptoms, review lab results, and diagnose and treat diseases. Some cases must be solved by your readers.