Best friends with perfect lives. That's what everyone who knows Liz and Cassie sees. Perfect houses, perfect husbands, perfect careers... but nothing is ever perfect. Each woman feels dissatisfied, harboring a desperate desire for something more in her life, secretly caving under the pressures of adulthood. Through nearly two decades of friendship, Cassie and Liz have confided in each other over everything from wardrobe decisions to major life choices. But not this time. Cassie, the overly driven ENT surgeon, aches to be a mother. Liz, the sassy plastic surgeon, craves a spicy romance. When desperation leads to betrayal, the women lose the one constant in their lives: each other. Amidst heartache and forgiveness, both women will see the purpose of their painful journey and learn that fate leads you right where you need to be.