This issue of Thoracic Surgery Clinics of North America, guest edited by Dr. Joshua Sonett, is devoted to Thymectomy for Myasthenia Gravis. Dr. Sonett has assembled expert authors to review the following topics: Role of Thymus in the Immune System; A Neurologist’s Perspective to Understanding Myasthenia Gravis: Clinical Perspectives of Etiology, Diagnosis and Preoperative Treatment; A Neurologist’s Perspective on Thymectomy for Myasthenia Gravis: Current Perspective and Future Trials and Medications; Surgical Approaches to Myasthenia Gravis: Perspective of Anatomy and Radicality in Surgery; Surgical Techniques for Myasthenia Gravis: VATS; Surgical Techniques for Myasthenia Gravis: RATS; Surgical Decision Making: Thymoma and Myasthenia Gravis; Immune Syndromes and the Thymus: Is There a Role of Thymectomy?; Surgical Techniques for Myasthenia Gravis: Transcervical; Surgical Technique for Myasthenia Gravis: Subxyphoid Approach; History of Thymectomy for Myasthenia Gravis; and more!