Platelet-rich fibrin (PRF) has emerged as a revolutionary biomaterial in regenerative medicine and dentistry, offering significant potential for enhancing tissue healing and repair. Derived from autologous blood, PRF is created through a simplified process without chemical additives, resulting in a fibrin-based matrix enriched with platelets, leukocytes, and cytokines. This unique composition provides a conducive environment for cellular proliferation, vascularization, and immune response, making PRF an ideal scaffold for tissue regeneration.The ability of PRF to promote angiogenesis, support epithelial migration, and enhance immunity has expanded its applications in soft and hard tissue regeneration. Its role in wound healing, bone repair, and integration with bone grafts highlights its versatility and effectiveness. Moreover, the use of PRF in conjunction with dental implants has demonstrated promising outcomes in improving bone quality, implant stability, and overall treatment success.