This monograph defines public sector entrepreneurship in terms of innovative public policy initiatives that generate greater economic prosperity by transforming a status quo economic environment into one that is more conducive to economic units engaging in creative activities in the face of uncertainty. Based on that definition, the author examines Vannevar Bush as an example of a public sector entrepreneur. Using Bush and the Bayh-Dole Act of 1980 as an example of public sector entrepreneurship, the monograph provides a framework that can serve as a unifying taxonomy for interpreting future research on public sector entrepreneurship.