This book offers an innovative approach to evaluating information and knowledge and its relation to the good life, in the Age of Autonomous Intelligent Machines, through the concept of Wisdom. Wisdom is understood as a type of meta-information and meta-knowledge, which comprises epistemic, ethical, and eudaimonic features, and provides a direct conceptual and practical link between the concepts of information, intelligence, knowledge, the good life, and wellbeing. More generally, it provides a direct link between technology and in particular Information Communication Technology (ICT) and Artificial Intelligence (AI) technologies, the good life and wellbeing. As such, the concept of wisdom allows for a direct normative evaluation of the impact the dissemination of information through ICTs and AI technologies have on the wellbeing of individuals and society at large. It provides a theoretical rationale to demonstrate the important and relevant role that wisdom plays in the specific evaluation of information in the digital and technological age in which we now live. To that end, a methodological approach is used in this book to show how some different general types of practical manifestations of digital information and intelligence can be normatively evaluated (if they are good or bad for us) through the application of the concept of wisdom. Edward H. Spence draws from the Stoics to present a neo-Stoic account of wisdom, which he then then applies to the technologies in question.