This book examines four medical innovations that epitomize the pitfalls of progress: DES, a synthetic estrogen prescribed to millions of women to prevent miscarriages, which produced devastating side effects; the artificial heart; the 1976 swine flu immunization program; and genetic engineering. Dutton and the contributors trace the human choices that govern medical and scientific innovation and explore the political, economic, and social factors that influence those choices. In the process, they reveal a deep gulf between the priorities of medical innovation and the concerns of the general public. They then propose concrete policy changes to help bridge that gulf.